Interaction between insulin receptors and glucose transport: Effect of prostaglandin E2

The effect of prostaglandin E₂ on the adipocyte glucose transport system was measured. Prostaglandin E₂ enhanced insulin's effects to accelerate adipocyte glucose transport without increasing insulin binding. However, prostaglandin E₂ did not increase transport in the absence of insulin, and is thus not an insulin-like agent. This augmenting effect appeared specific for the insulin stimulatory process since prostaglandin E₂ did not enhance the ability of “insulin-like” agents to increase glucose transport. These results suggest that prostaglandin E₂ may play a role in the interaction between insulin receptors and the glucose transport system.