Demonstration of a receptor on rabbit neutrophils for chemotactic peptides |
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| Authors: | Srinivasabhatt Aswanikumar Barbara Corcoran Elliot Schiffmann Alan R Day Richard J Freer Henry J Showell Elmer L Becker Candace B Pert |
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| Institution: | Laboratory of Developmental Biology and Anomalies National Institute of Dental Research, National Institutes of Health Bethesda, Maryland 20014 USA;Department of Pharmacology, Medical College of Virginia Richmond, Virginia 23298 USA;Department of Pathology, University of Connecticut Health Center Farmington, Conn., 06032 USA;Section on Biochemistry, Adult Psychiatry Branch National Institute of Mental Health, Bethesda, Maryland 20014 USA |
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| Abstract: | 3H]formylNorleu-Leu-Phe, a potent leucocyte chemoattractant, binds specifically to a site on rabbit neutrophils with an affinity of 1.5 × 10?9 M. Other acylated peptide chemoattractants displace this binding at concentrations closely related to those levels required to elicit chemotaxis. The binding fulfills the major criteria for demonstration of specific receptor sites and indicates that a natural bacterial product and synthetic formyl-peptides produce chemotaxis by the same receptor mechanism. |
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