Induction of differentiation in mouse neuroblastoma cells by hexamethylene bisacetamide |
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| Authors: | Clive Palfrey Yosef Kimhi UZ Littauer Roberta C Reuben Paul A Marks |
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| Institution: | Department of Neurobiology Weizmann Institute of Science Rehovot, Israel;Department of Medicine and Human Genetics and Development and Cancer Center, Columbia University College of Physicians & Surgeons New York, New York 10032, USA |
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| Abstract: | Hexamethylene bisacetamide (HMBA), a potent inducer of erythroid differentiation in murine erythroleukemia cells (1), induces differentiation in mouse neuroblastoma cells, as indicated by the extension of neurites and the development of an excitable membrane. HMBA is effective at concentrations 50-fold lower than dimethylsulfoxide (2), another inducer of differentiation in both mouse neuroblastoma and murine erythroleukemia cells. |
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| Keywords: | HMBA hexamethylene bisacetamide MELC murine erythroleukemia cells AChE acetylcholinesterase dimethylsulfoxide |
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