Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice |
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Authors: | Kim Dong Hyun Kim Do Yoon Kim Young Choong Jung Ji Wook Lee Seungjoo Yoon Byung Hoon Cheong Jae Hoon Kim Yeong Shik Kang Sam Sik Ko Kwang Ho Ryu Jong Hoon |
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Affiliation: | Department of Oriental Pharmaceutical Science and East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Hoeki-dong, Dongdaemoon-Ku, Seoul 130-701, Republic of Korea. |
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Abstract: | Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas. In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance test and the Y-maze test (P<0.05), and also reduced escape latency during training in the Morris water maze test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study. These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling. |
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Keywords: | Nodakenin Memory Passive avoidance test Y-maze test Morris water maze Acetylcholinesterase |
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