Conference overview: Molecular mechanisms of metal toxicity and carcinogenesis |
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Authors: | Jacquelyn J Bower Stephen S Leonard Xianglin Shi |
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Institution: | (1) Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA;(2) Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia, USA;(3) Pathology & Physiology Research Branch, National Institute for Occupational Safety & Health, West Virginia University, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA |
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Abstract: | Chronic exposure to many heavy metals and metal-derivatives is associated with an increased risk of cancer, although the mechanisms
of tumorigenesis are largely unknown. Approximately 125 scientists attended the 3rd Conference on Molecular Mechanisms of
Metal Toxicity and Carcinogenesis and presented the latest research concerning these mechanisms. Major areas of focus included
exposure assessment and biomarker identification, roles of ROS and antioxidants in carcinogenesis, mechanisms of metal-induced
DNA damage, metal signalling, and the development of animal models for use in metal toxicology studies. Here we highlight
some of the research presented, and summarize the conference proceedings. |
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Keywords: | antioxidants carcinogenesis DNA damage metals reactive oxygen species |
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