| 铁与帕金森病关系研究进展 |
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| 引用本文： | 郭春彦,陈忻.铁与帕金森病关系研究进展[J].中国实验动物学报,2011,19(4):I0003-I0008. |
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| 作者姓名： | 郭春彦 陈忻 |
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| 作者单位： | 首都医科大学中医药学院,北京,100069 |
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| 基金项目： | 北京市教育委员会科技发展计划项目[KM201110025010] |
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| 摘 要： | 大量研究证实帕金森患者黑质铁异常沉积,脑内铁代谢紊乱,铁促进氧化应激是神经细胞损伤的重要病理机制。本文综述了铁代谢异常与帕金森病关系的研究概况,指出从中药中寻找金属螯合活性成分治疗PD是极其诱人的研究方向。
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| 关 键 词： | 铁 帕金森病 氧化应激 铁螯合剂 |
Advances in research on the association between iron and Parkinson's disease |
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| GUO Chun-yan,CHEN Xin.Advances in research on the association between iron and Parkinson's disease[J].Acta Laboratorium Animalis Scientia Sinica,2011,19(4):I0003-I0008. |
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| Authors: | GUO Chun-yan CHEN Xin |
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| Institution: | GUO Chun-yan,CHEN Xin(School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China) |
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| Abstract: | Numerous studies have reported the abnormal accumulation of iron in substantia nigra in patients with Parkinson＇s disease and the disordered brain iron metabolism. Iron promoting oxidative stress is an important pathological mechanism of neuronal damage. This paper will review the association of iron and Parkinson＇s disease, and point out the attractive perspective of metal chelator from TCM in future research on the treatment of Parkinson＇s disease. |
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| Keywords: | iron Parkinson's disease Oxidative stress Ferrochelatase |
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