| 铜绿假单胞菌必需基因的研究进展 |
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| 引用本文： | 张明月,胡福泉,黄广涛. 铜绿假单胞菌必需基因的研究进展[J]. 微生物学通报, 2021, 48(6): 2143-2154 |
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| 作者姓名： | 张明月 胡福泉 黄广涛 |
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| 作者单位： | 1 遵义医科大学第一临床学院 贵州 遵义 563000;2 陆军军医大学(第三军医大学)基础医学院微生物学教研室 重庆 400038;3 遵义医科大学附属医院烧伤整形外科 贵州省临床(创面修复)研究中心 贵州 遵义 563000 |
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| 基金项目： | 国家自然科学基金(81801916，81960353)；贵州省科技计划(2020-4Y003，2020-1Y332)；遵义市科技局联合基金(HZ-2019-50) |
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| 摘 要： | 铜绿假单胞菌为专性需氧非发酵革兰氏阴性杆菌,是医院感染的常见条件致病菌之一,可引起呼吸道、泌尿道、烧伤创面和菌血症等严重感染.铜绿假单胞菌耐药形势日益严峻,给临床治疗带来困难.必需基因是生长过程中必不可少的看家基因,对铜绿假单胞菌必需基因进行深入研究,不仅有助于了解细菌的生长、毒力等基本特性,也有助于筛选新的抗菌药物靶...
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| 关 键 词： | 铜绿假单胞菌 必需基因 转座子 生物信息学 CRISPRi |
Progress of essential genes in Pseudomonas aeruginosa |
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| ZHANG Mingyue,HU Fuquan,HUANG Guangtao. Progress of essential genes in Pseudomonas aeruginosa[J]. Microbiology China, 2021, 48(6): 2143-2154 |
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| Authors: | ZHANG Mingyue HU Fuquan HUANG Guangtao |
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| Affiliation: | 1 The First Clinical Institute, Zunyi Medical University, Zunyi, Guizhou 563000, China;2 Department of Microbiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Chongqing 400038, China; 3 Department of Burn Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Guizhou Clinical (Wound Healing) Research Center, Zunyi, Guizhou 563000, China |
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| Abstract: | Pseudomonas aeruginosa (P. aeruginosa), an obligatory aerobic non-fermented Gram-negative bacterium, is one of the common opportunistic pathogens of nosocomial infection. P. aeruginosa can cause severe infection such as respiratory tract, urinary tract, burn wounds and bacteremia. The antibiotic resistance of P. aeruginosa spread widely, which brings difficulties to clinical treatment. Essential genes are indispensable genes for organisms to grow. Investgation of P. aeruginosa essential genes could help us to understand the basic characteristics of bacteria such as growth and virulence, and could also help us to screen new targets of antibacterial agents. This paper will summary the progress of P. aeruginosa essential genes, including basic physiological characteristics of P. aeruginosa, the research methods of essential genes and the progress and significance of P. aeruginosa essential genes. |
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| Keywords: | Pseudomonas aeruginosa essential genes transposon bioinformatics CRISPRi |
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