The effect of amylin and calcitonin gene-related peptide on insulin-stimulated glucose transport in the diaphragm |
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| Authors: | J S Hothersall R P Muirhead S Wimalawansa |
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| Affiliation: | Department of Biochemistry, University College, London, UK. |
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| Abstract: | The two peptides calcitonin gene related peptide (CGRP) and amylin at 1 uM levels in an isolated rat diaphragm preparation inhibited insulin stimulated 2-deoxy[3H]glucose transport by 30 and 60 percent, respectively; this was the case at maximal (1 uM) and sub-maximal (0.5 mU) insulin concentrations. No effect was measured on the basal level of 2-deoxy[3H]glucose transport. |
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