Manganese superoxide dismutase expressed in silkworm larvae,Bombyx mori L enhances the NK activity and splenocyte proliferation against Sarcoma 180 tumor cells in vivo |
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Authors: | Yue Wan-Fu Yao Min-Li Liu Jian-Mei Li Guang-Li Li Xing-Hua Wu Xiao-Feng Deng Wen Sun Hong-Xiang Zhou Ji-Yong Zhang Chuan-Xi Miao Yun-Gen |
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Institution: | (1) Institute of Sericulture and Apiculture, Zhejiang University, Hangzhou, 310029, P.R. China;(2) College of Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, P.R. China;(3) Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, P.R. China;(4) Institute of Insect Sciences, Zhejiang University, Hangzhou, 310029, P.R. China |
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Abstract: | Natural killer cell (NK) is known as a major immune system in body through mediating cell death via several possible pathways,
and one of three subpopulations of lymphocytes functioning as scavenger of tumor, virus infected cells etc. Our present results
found that the SOD-contained silkworm larvae powder caused an enhancement of the effect on NK cell cytotoxicity, which implied
this material modulated the immune system in mice in vivo. The NK cell activities of S180 tumor modeled mice treated with
silkworm powder including SOD were enhanced significantly ranging from 30% to 48%, respectively, compare to a distilled water
feeding control and silkworm powder without SOD. Meanwhile, the ConA-stimulated splenocyte proliferation of all three treated
groups was higher than that of the control both in T cells or B cells. The average tumor weight of S180 modeled mice treated
with doses of SOD-contained silkworm powder was lighter than that of water control showing the tumor inhibition rates (IR)
reached to 22.51% to 37%, respectively. In conclusion, these findings demonstrate that administration of silkworm larvae powder
containing SOD results in activation of NK cells and immune T-cell and B-cell, suggesting the silkworm larvae powder containing
SOD play a positive role in tumor inhibition. |
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Keywords: | SOD-contained silkworm powder Natural killer (NK) cells Sarcoma 180 (S180) tumor modeled mice Immune regulation Splenocyte proliferation T-cells and B-cells |
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