Calcium Channels: Unanswered Questions |
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| Authors: | Stephen W Jones |
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| Institution: | Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA. swj@cwru.edu |
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| Abstract: | Despite decades of intensive research, many questions remain unresolved regarding the structure and function of voltage-dependent calcium channels. This review considers some of those questions: Where is the activation gate? Where are the inactivation gates? How are the voltage sensors coupled to the gates? Are bacterial K+ channels good models for the Ca2+ channel pore? Are protein–protein interactions fundamental to Ca2+ channel function? Do voltage-dependent Ca2+ channels regulate basal intracellular Ca2+? Are N and P/Q channels specialized for fast neurotransmitter release? |
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| Keywords: | Gating permeation activation inactivation modulation subunit transmitter release voltage allosteric model |
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