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Second-generation dimeric inhibitors of chitin synthase |
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| Authors: | Yeager Adam R Finney Nathaniel S |
| Affiliation: | aUniversity of California, San Diego, Department of Chemistry and Biochemistry, 9500 Gilman Dr. La Jolla, CA 92093-0358, USA bOrganisch-chemisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland |
| Abstract: | Chitin synthase (CS) is essential for fungal cell wall biosynthesis and is an attractive medicinal target. Expanded results from our efforts to develop mechanism based inhibitors of CS are presented here. Specifically, we describe uridine dimers linked by tartrate amides as potential pyrophosphate mimics. |
| Keywords: | Glycosyltransferase, Mechanism Inhibitor Phosphate mimic |
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