Computer simulation for effect of Pr(III) on Ca(II) speciation in human interstitial fluid |
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| Authors: | Haiyuan Zhang Xing Lu Jinping Wang Kuiyue Yang Chunji Niu Jiazuan Ni |
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| Affiliation: | (1) Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022 Changchun, People’s Republic of China |
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| Abstract: | A multiphase model of metal ion speciation in human interstitial fluid was constructed and the effect of Pr(III) on Ca(II) speciation was studied. Results show that free Ca2+, [Ca(HCO3)], and [Ca(Lac)] are the main species of Ca(II). Because of the competition of Pr(III) for ligands with Ca(II), the percentages of free Ca2+, [Ca(Lac)], and [Ca(His)(Thr)H3] increase gradually and the percentages of CaHPO4(aq) and [Ca(Cit)(His)H2] decrease gradually with the increase in the total concentration of Pr(III). However, the percentages of [Ca(HCO3)] and CaCO3(aq) first increase and then begin to decrease when the total concentration of Pr(III) exceeds 6.070×10−4 M. |
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| Keywords: | Computer simulation praseodymium(III) calcium(II) speciation human interstitial fluid |
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