1. School of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA;2. Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA;3. Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA;4. Departments of Medicine, Genetic Medicine, and Surgery, Weill Cornell Medical College, New York, NY 10021, USA;5. Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10021, USA;6. Department of Radiology, Weill Cornell Medical College, New York, NY 10021, USA;7. HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine and Cancer Center, Weill Cornell Medical College, New York, NY 10021, USA
Abstract:
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Highlights? miR-34a regulates colon cancer stem cell asymmetric division ? miR-34a generates a sharp threshold response ? miR-34a converts Notch signaling into a toggle switch ? Binary Notch levels specify self-renewal versus differentiation
