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Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells
Authors:Raul Vizcardo  Kyoko Masuda  Daisuke Yamada  Tomokatsu Ikawa  Kanako Shimizu  Shin-ichiro Fujii  Haruhiko Koseki  Hiroshi Kawamoto
Institution:1. Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Yokohama 230-0045, Japan;2. Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama 230-0045, Japan;3. Research Unit for Therapeutic Model, RIKEN Research Center for Allergy and Immunology, Yokohama 230-0045, Japan;4. Research Unit for Cellular Immunotherapy, RIKEN Research Center for Allergy and Immunology, Yokohama 230-0045, Japan;5. Department of Immune Regulation Research, Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba 260-8670, Japan
Abstract:
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  • Highlights? iPSCs generated from T cells specific for the MART-1 melanoma epitope ? Differentiation of iPSCs into T cells with a MART-1 specific T cell receptor ? MART-1-based stimulation of T cells demonstrates retained antigen specificity
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