1. Department of Pediatrics and Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA 92093-0695, USA;2. Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA;3. ViaCyte Inc., 3550 General Atomics Court, San Diego, CA 92121, USA
Abstract:
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Highlights? Pancreatic lineage progression is governed by PcG-dependent chromatin remodeling ? A temporal chromatin signature predicts regulators of pancreatic development ? Endocrine cells differentiated from hESCs in vivo are similar to native human islets ? In vitro-produced malfunctioning endocrine cells exhibit aberrant chromatin structure
