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Anesthetics Rapidly Promote Synaptogenesis during a Critical Period of Brain Development
Authors:Mathias De Roo  Paul Klauser  Adrian Briner  Irina Nikonenko  Pablo Mendez  Alexandre Dayer  Jozsef Z Kiss  Dominique Muller  Laszlo Vutskits
Institution:1. Department of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; 2. Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, Geneva, Switzerland.; 3. Department of Adult Psychiatry, University Hospital of Geneva, Geneva, Switzerland.;Institut de la Vision, France
Abstract:Experience-driven activity plays an essential role in the development of brain circuitry during critical periods of early postnatal life, a process that depends upon a dynamic balance between excitatory and inhibitory signals. Since general anesthetics are powerful pharmacological modulators of neuronal activity, an important question is whether and how these drugs can affect the development of synaptic networks. To address this issue, we examined here the impact of anesthetics on synapse growth and dynamics. We show that exposure of young rodents to anesthetics that either enhance GABAergic inhibition or block NMDA receptors rapidly induce a significant increase in dendritic spine density in the somatosensory cortex and hippocampus. This effect is developmentally regulated; it is transient but lasts for several days and is also reproduced by selective antagonists of excitatory receptors. Analyses of spine dynamics in hippocampal slice cultures reveals that this effect is mediated through an increased rate of protrusions formation, a better stabilization of newly formed spines, and leads to the formation of functional synapses. Altogether, these findings point to anesthesia as an important modulator of spine dynamics in the developing brain and suggest the existence of a homeostatic process regulating spine formation as a function of neural activity. Importantly, they also raise concern about the potential impact of these drugs on human practice, when applied during critical periods of development in infants.
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