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Defining Influenza A Virus Hemagglutinin Antigenic Drift by Sequential Monoclonal Antibody Selection

Authors:	Suman R Das Scott E Hensley William L Ince Christopher B Brooke Anju Subba Mark G Delboy Gustav Russ James S Gibbs Jack R Bennink Jonathan W Yewdell

Institution:	1. Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA;2. Infectious Diseases Group, J. Craig Venter Institute, Rockville, MD 20850, USA;3. Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA;4. Institute of Virology, Slovak Academy of Sciences, 84505 Bratislava, Slovak Republic

Abstract:	Download : Download high-res image (376KB) Download : Download full-size image Highlights? Influenza hemagglutinin (HA) easily accumulates substitutions while maintaining function ? Twelve amino acid substitutions enable complete escape from neutralizing antibodies ? Escape mutations in HA can require epistatic mutations in neuraminidase ? HA escape mutation space changes with each substitution, making predictions difficult

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