1. Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;3. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;4. Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;5. Department of Neurologic Surgery, Department of Biochemistry and Molecular Biology, Mayo College of Medicine, Rochester, MN 55905, USA;6. Department of Pediatrics, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;7. School of Life Sciences, Tsinghua University, Beijing 100081, P.R. China
Abstract:
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Highlights? Wnt inhibitor sFRP3 exhibits activity-dependent expression in the adult hippocampus ? sFRP3 maintains quiescence of adult hippocampal radial glia-like neural stem cells ? sFRP3 inhibits maturation, dendritic development, and spinal formation of new neurons ? sFRP3 partially mediates activity-dependent adult hippocampal neurogenesis
