1. Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, 185 Cambridge Street, Boston, MA 02114, USA;2. Harvard Stem Cell Institute, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA;3. Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, 7 Divinity Avenue, Cambridge, MA 02138, USA;4. Center for Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA;5. Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA;6. Division of Hematology/Oncology, Children’s Hospital, Boston, MA 02115, USA;7. Informatics Program, Children’s Hospital, Boston, MA 02115, USA;8. Division of Genetics, Brigham and Women’s Hospital, Boston, MA 02115, USA