Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog |
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| Authors: | Violetta Karwacki-Neisius,Jonathan Göke,Rodrigo Osorno,Florian Halbritter,Jia Hui Ng,Andrea Y. Weiße,Frederick C.K. Wong,Alessia Gagliardi,Nicholas P. Mullin,Nicola Festuccia,Douglas Colby,Simon R. Tomlinson,Huck-Hui Ng,Ian Chambers |
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| Affiliation: | 1. MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, Scotland, UK;2. SyntheSys, Synthetic & Systems Biology, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JD, Scotland, UK;3. Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672, Singapore;4. Graduate School for Integrative Sciences and Engineering, Department of Biological Sciences, and Department of Biochemistry, National University of Singapore, Singapore 117597, Singapore;5. School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore |
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