1. Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA;2. James Hogg Research Centre, Institute for Heart + Lung Health, St. Paul’s Hospital, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada;3. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada
Abstract:
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Highlights? Intracellular signaling predicts the fate of coxsackievirus B3 (CVB3)-infected cells ? p38 and ERK signaling pathways are tightly interconnected during CVB3 infection ? CVB3-induced apoptosis of cardiomyocytes is inhibited by ERK5 and ERK1/2 pathways ? CVB3 induces necrosis of cardiomyocytes via p38 activation
