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Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

Authors:	Shugo Tohyama Fumiyuki Hattori Motoaki Sano Takako Hishiki Yoshiko Nagahata Tomomi Matsuura Hisayuki Hashimoto Tomoyuki Suzuki Hiromi Yamashita Yusuke Satoh Toru Egashira Tomohisa Seki Naoto Muraoka Hiroyuki Yamakawa Yasuyuki Ohgino Tomofumi Tanaka Masatoshi Yoichi Shinsuke Yuasa Keiichi Fukuda

Institution:	1. Department of Cardiology, Keio University School of Medicine, Tokyo 160-8582, Japan;2. Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan;3. Japan Society for the Promotion of Science, Tokyo 102-8472, Japan;4. Asubio Pharma, Kobe 650-0047, Japan;5. Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Suematsu Gas Biology Project, Tokyo 160-8582, Japan;6. Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan

Abstract:	Download : Download high-res image (592KB) Download : Download full-size image Highlights? Integrated “omic” analyses reveal metabolic hallmarks in ESCs and cardiomyocytes ? Glucose depletion and lactate supplementation can purify PSC-derived cardiomyocytes ? Cardiomyocytes can use lactate efficiently for energy metabolism ? Transplanted purified human ESC-derived cardiomyocytes do not form tumors

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