Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming

Authors:	Yawei Gao Jiayu Chen Ke Li Tong Wu Bo Huang Wenqiang Liu Xiaochen Kou Yu Zhang Hua Huang Yonghua Jiang Chao Yao Xiaolei Liu Zhiwei Lu Zijian Xu Lan Kang Jun Chen Hailin Wang Tao Cai Shaorong Gao

Institution:	1. Graduate School of Peking Union Medical College, Beijing 100730, China;2. National Institute of Biological Sciences, Beijing 102206, China;3. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Science, Beijing 100085, China

Abstract:	Download : Download high-res image (350KB) Download : Download full-size image Highlights? Tet1 facilitates iPSC induction by promoting Oct4 demethylation and reactivation ? Tet1 can replace Oct4 to generate fully pluripotent TSKM iPSCs ? Both 5mC and 5hmC increase on the genome during TSKM 2° reprogramming ? 5hmC promotes the demethylation of pluripotency genes during reprogramming

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