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Identification of Distinct Ligands for the C-type Lectin Receptors Mincle and Dectin-2 in the Pathogenic Fungus Malassezia
Authors:Tetsuaki Ishikawa  Fumie Itoh  Sayumi Yoshida  Shinobu Saijo  Tetsuhiro Matsuzawa  Tohru Gonoi  Takashi Saito  Yoshio Okawa  Nobuyuki Shibata  Tomofumi Miyamoto  Sho Yamasaki
Institution:1. Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka 812-8582, Japan;2. Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka 812-8582, Japan;3. Research Center for Advanced Immunology, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka 812-8582, Japan;4. Department of Infection and Host Defense, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan;5. Department of Molecular Immunology, Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba 260-8673, Japan;6. Department of Bio-resources, Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba 260-8673, Japan;7. Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Saitama 332-0012, Japan;8. Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama 230-0045, Japan;9. WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan
Abstract:
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  • Highlights? Mincle and Dectin-2 cooperatively recognize Malassezia through distinct ligands ? The Mincle ligands in Malassezia are glucosyl- and mannosylglycolipids ? The Dectin-2 ligand in Malassezia is an O-linked mannobiose-rich glycoprotein ? Cytokine response to the respective ligands was impaired in Mincle?/? and Dectin-2?/? DCs
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