Abyssinones and related flavonoids as potential steroidogenesis modulators |
| |
Authors: | Kaushik S Hatti Latha Diwakar G Venkateswara Rao Anil Kush G Chandrasekara Reddy |
| |
Affiliation: | Vittal Mallya Scientific Research Foundation, PB No 406, K.R. Road; Bangalore 560004, India |
| |
Abstract: | Abyssinones and related flavonoids were screened against 3 enzymes (3βHSD, 17βHSD and Aromatase) of steroidogenesis pathway. The virtual screening experiment shows high affinity for flavonones than their respective chalcones. A 4'' OH blocked prenylated flavonone 2b (2(2'', 2''dimethyl chroman6''yl)7hydroxy chroman4one) had consistent binding affinity to all the three enzymes used in this study showing higher binding affinity to aromatase. A good correlation was observed between cytotoxic data (MCF7, breast cancer cell line) and docking results indicating flavonone as a better steroidogenesis modulator in hormone dependent cancer. |
| |
Keywords: | flavonoids steoidogenesis modulators docking model cancer |
|