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Stage-Specific Roles for Tet1 and Tet2 in DNA Demethylation in Primordial Germ Cells
Authors:John J Vincent  Yun Huang  Pao-Yang Chen  Suhua Feng  Joseph H Calvopiña  Kevin Nee  Serena A Lee  Thuc Le  Alexander J Yoon  Kym Faull  Guoping Fan  Anjana Rao  Steven E Jacobsen  Matteo Pellegrini  Amander T Clark
Institution:1. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA;2. Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA;3. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA;4. Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA;5. Pasarow Mass Spectrometry Laboratory, University of California, Los Angeles, Los Angeles, CA 90095, USA;6. Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA;7. La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA;8. Institute of Plant and Microbial Biology, Academia Sinica, Taipei 11529, Taiwan, ROC
Abstract:
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  • Highlights? PGCs differentiated from ESCs undergo genome-wide DNA demethylation ? Tet1 and Tet2 do not regulate genome-wide DNA demethylation in PGCs ? Tet1 and Tet2 regulate locus-specific demethylation in PGCs
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