1. Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, Germany;2. Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany;3. Department of Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany;4. Institute of Neuropathology, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A7, 48149 Münster, Germany;5. Graduate School of Cellular & Molecular Neuroscience, University of Tübingen, 72076 Tübingen, Germany;6. Department of Orthopaedic Surgery, University of Tübingen, 72076 Tübingen, Germany;7. Cellular Biophysics Group, Institute for Medical Physics and Biophysics, Westfälische Wilhelms-Universität Münster, Robert-Koch Str. 31, 41849 Münster, Germany;8. Department of Pharmacology, Lead-Discovery-Center GmbH, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany;9. Medical Faculty, University of Münster, Domagkstrasse 3, 48149 Münster, Germany
Abstract:
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Highlights? hiPSC-derived neurons with LRRK2 G2019S exhibit Parkinsonian neurodegeneration ? Genetic correction of the LRRK2 mutation rescued neurodegenerative phenotypes ? Comparative analysis links LRRK2 G2019S, gene dysregulation, and ERK activation ? ERK-dependent gene dysregulation by LRRK2 G2019S contributes to neurodegeneration
