首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Polarized distribution of GM1-ganglioside in human duodenal absorptive enterocytes as visualized with cholera toxin-gold complex
Authors:Jürgen Roth
Institution:(1) Interdepartmental Electron Microscopy, Biocenter, University of Basle, CH-4056 Basle, Switzerland
Abstract:Cholera toxin bound to particles of colloidal gold was used to investigate by electron microscopy the binding of the toxin in human duodenum. Cholera toxin binding was detected only in the apical (brush border) plasma membrane domain suggesting that the ganglioside GM1 is absent from the basolateral plasma membrane domain. Intracellularly, toxin binding became detectable in thetrans side of the Golgi apparatus. Labeling of endosomes may indicate that the non toxin-occupied GM1-ganglioside becomes internalized.
Keywords:cholera toxin-gold  ganglioside G M1   electron microscopy  human duodenum  brush border  receptor cycling
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号