Coenzyme Q treatment of neurodegenerative diseases of aging |
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| Institution: | 1. National Institute of Neurological Disorders and Stroke, National Institutes of Health, 6001 Executive Blvd., Room 2225, Bethesda, MD 20892, USA;2. Massachusetts General Hospital East, Neurology Clinical Trials Unit, CNY Building 149, Room 2274, Charlestown, MA 02129, USA;1. Department of Cardiology, Cardiac Imaging Department, Prince Sultan Cardiac Center-Qassim (PSCCQ), King Fahad Specialist Hospital, Buraydah, aSaudi Arabia;1. Cardiology Department, Ain Shams University Hospital, Cairo, aEgypt;1. Division of Cardiac Surgery, Department of Cardiac Sciences, King Saud bin Abduaziz University for Health Sciences, National Guard Health Affairs, Riyadh, aSaudi Arabia;1. Department of Medicine, Ministry of National Guard—Health Affairs, Riyadh, aSaudi Arabia;2. Advanced Cardiac Imaging, King Abdulaziz Cardiac Center, Ministry of National Guard—Health Affairs, Riyadh, bSaudi Arabia;1. Department of Internal Medicine M3, University of Medicine and Pharmacy, 38 Gheorghe Marinescu Street, 540139 Tirgu Mures, RomaniaaRomania;2. Department of Cardiology, Institute for Cardiovascular Disease and Heart Transplant, 50 Gheorghe Marinescu Street, 540136 Tirgu Mures, RomaniabRomania;3. Department of Morphologic Sciences M1, University of Medicine and Pharmacy, 38 Gheorghe Marinescu Street, 540139 Tirgu Mures, RomaniacRomania;4. Department of Radiology, Emergency County Clinical Hospital, 50 Gheorghe Marinescu Street, 540136 Tirgu Mures, RomaniadRomania |
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| Abstract: | The etiology of several neurodegenerative disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q-10 (CoQ10) acts both as an antioxidant and as an electron acceptor at the level of the mitochondria. In several animal models of neurodegenerative diseases including amyotrophic lateral sclerosis, Huntington’s disease, and Parkinson’s disease, CoQ10 has shown beneficial effects. Based on its biochemical properties and the effects in animal models, several clinical trials evaluating CoQ10 have been undertaken in many neurodegenerative diseases. CoQ10 appears to be safe and well tolerated, and several efficacy trials are planned. |
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