Gender-Specific Clinical Characteristics of Deep Q Waves in Hypertrophic Cardiomyopathy |
| |
| Institution: | 1. School of Social Work, The University of Texas at Austin, 1925 San Jacinto Boulevard, Austin, TX 78712, USA;2. Population Research Center, The University of Texas at Austin, 305 E. 23rd Street Stop G1800, Austin, TX 78712, USA;1. FACT (French Alliance for Cardiovascular Trials), Paris, France;2. Cardiology Department, Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Paris, France;3. Brigham and Women''s Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA, USA;4. Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, and INSERM U1148, Paris, France;5. Université de Paris, Paris, France;6. Duke University Medical Center, Durham, NC, USA;7. Department of Medicine, Tokai University School of Medicine, Isehara, Japan;8. University of Michigan Health System, Ann Arbor, MI, USA;9. Atlanta VA Medical Center and Emory Cardiovascular Research Institute, GA, USA;10. Heart and Vascular Center, University of North Carolina at Chapel Hill, NC, USA;11. NHLI Imperial College, ICMS, Royal Brompton Hospital, London, United Kingdom |
| |
| Abstract: | Background: Despite male predominance in the prevalence of hypertrophic cardiomyopathy (HCM), repeated diagnosis at our institute indicates a possible higher prevalence of deep Q waves with HCM in women.Objective: The current study examined gender similarities and differences in the prevalence of deep Q waves in HCM and in the morphologic and electrocardiographic features of HCM with deep Q waves.Methods: Patients with HCM underwent cardiac magnetic resonance (CMR) imaging to identify the prevalence of deep Q waves in electrocardiographic limb leads, and to analyze the relationship between distribution patterns of deep Q waves and those of the localization of maximum amplitude of left ventricular (LV) hypertrophy. Contiguous LV short-axis images were obtained from the base toward the apex.Results: Of the 200 consecutive patients (172 males, aged 20–78 years; 28 females, aged 16–79 years) with HCM who underwent CMR imaging, 10 male and 8 female patients had deep Q waves. Deep Q waves were more prevalent in females with HCM than in their male counterparts (28.6% vs 5.8%, respectively; P < 0.001). Of the 18 patients with deep Q waves, maximum wall thickness was localized at either the basal anterior wall or the midventricular septum in 9 (90%) of the 10 male patients and 6 (75%) of the 8 female patients. In both sexes, the Q wave distribution pattern of I and aVL and of II and aVF indicated localization of maximum hypertrophy at the midventricular septum in 6 (75%) of the 8 patients with the former pattern, and at the basal anterior wall in 9 (90%) of the 10 patients with the latter pattern.Conclusions: Diagnostic deep Q waves were detected more frequently in female patients with HCM than in their male counterparts. In HCM with deep Q waves in limb leads, morphologic and electrocardiographic analysis showed similar features in both sexes. (Gend Med.Keywords: deep Q wave, hypertrophic cardiomyopathy, gender, cardiac magnetic resonance. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
