Coenzyme Q10 in cardiovascular disease |
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| Affiliation: | 1. CJOB Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Australia;2. Departments of Surgery and of Epidemiology & Preventative Medicine, Monash University, Melbourne, Australia;3. Baker Heart Research Institute, Melbourne, Australia;1. Students'' Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran;2. Department of Rheumatology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;3. Road Traffic Injury Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran;4. Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran;1. Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;2. Student Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;3. Department of Biochemistry and Diet Therapy, Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;1. Department of Hypertension, Medical University of Lodz, Lodz, Poland;2. Department of Nephrology, Hypertension, and Family Medicine, Medical University of Lodz, Lodz, Poland;3. Department of Functional Sciences, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania;4. Centre for Interdisciplinary Research, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania;5. Department of Functional Sciences, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania;6. Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania;7. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;8. Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL;9. Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL;10. Preventive Cardiology, CGH Medical Center, Sterling, IL;11. The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD;12. Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy;13. University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK;14. Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London, London, UK;1. Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland;2. Department of Functional Sciences, Discipline of Pathophysiology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania;3. Department of Functional Sciences, Discipline of Public Health, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania;4. Department of Nephrology, Hypertension and Family Medicine, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland;5. Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA;6. Preventive Cardiology, CGH Medical Center, Sterling, IL, USA;7. The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA;8. Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Italy;9. Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA;10. Lipid Disorders Clinic, Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia;11. University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK;12. Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London, UK;13. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;1. Division of Cardiovascular Medicine, Department of Medicine and Health Sciences, Linköping University, Department of Cardiology, County Council of Östergötland, SE-581 85 Linköping, Sweden;2. Deptartment of Medicine, Innlandet Hospital Trust, N-2226 Kongsvinger, Norway |
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| Abstract: | In this review we summarise the current state of knowledge of the therapeutic efficacy and mechanisms of action of CoQ10 in cardiovascular disease. Our conclusions are: 1. There is promising evidence of a beneficial effect of CoQ10 when given alone or in addition to standard therapies in hypertension and in heart failure, but less extensive evidence in ischemic heart disease. 2. Large scale multi-centre prospective randomised trials are indicated in all these areas but there are difficulties in funding such trials. 3. Presently, due to the notable absence of clinically significant side effects and likely therapeutic benefit, CoQ10 can be considered a safe adjunct to standard therapies in cardiovascular disease. |
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