Endogenous synthesis of coenzyme Q in eukaryotes |
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| Affiliation: | 1. Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA, USA 90095–1569;2. Department of Chemistry and Biochemistry, California State University, Fullerton, Fullerton, CA, USA 92834 |
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| Abstract: | Coenzyme Q (Q) functions in the mitochondrial respiratory chain and serves as a lipophilic antioxidant. There is increasing interest in the use of Q as a nutritional supplement. Although, the physiological significance of Q is extensively investigated in eukaryotes, ranging from yeast to human, the eukaryotic Q biosynthesis pathway is best characterized in the budding yeast Saccharomyces cerevisiae. At least ten genes (COQ1–COQ10) have been shown to be required for Q biosynthesis and function in respiration. This review highlights recent knowledge about the endogenous synthesis of Q in eukaryotes, with emphasis on S. cerevisiae as a model system. |
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