Changes in the structural organization of the surface membrane in malignant cell transformation |
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Authors: | Hannah Ben-Bassat Michael Inbar Leo Sachs |
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Affiliation: | (1) Department of Genetics, Weizmann Institute of Science, Rehovot, Israel |
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Abstract: | Summary Malignant transformation of normal cells resulting in agglutinability by the carbohydrate-binding protein Concanavalin A can be explained by three types of changes in the structural organization of sites on the surface membrane. There can be an exposure of cryptic sites, a concentration of exposed sites by a decrease in cell size, and a rearrangement of exposed sites without a decrease in cell size resulting in a clustering of sites. |
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