Macromolecular mimicry in translation initiation: a model for the initiation factor IF2 on the ribosome |
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Authors: | Moreno J M Sørensen H P Mortensen K K Sperling-Petersen H U |
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Affiliation: | Department of Molecular and Structural Biology, Aarhus University, Denmark. |
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Abstract: | Protein biosynthesis in bacteria is controlled by a number of translation factors. Recent data based on comparison of sequence and structure data of translation factors have established a novel hypothesis for their interaction with the ribosome: initiation, elongation, and termination factors may use a common or partly overlapping binding site on the ribosome in a process of macromolecular mimicry of an A-site-bound tRNA. This paper reviews structural knowledge and tRNA macromolecular mimicry involvement of translation initiation factor IF2. Furthermore, a model is proposed for the factor and its interaction with the ribosome during the formation of the translation initiation complex. |
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