| Abstract: | Decreased hypercalcemic effects of PTH are observed after medulloadrenalectomy, (table I), metoprione (table II) or cortisone (table IV) treatments in guinea pigs. 2. Norepinephrine restores the blood calcium effects of PTH in these cases but epinephrine is inactive. 3. Immediate activation of kidney adenylate cyclase by PTH (increased urinary AMPc) is also reduced in medulloadrenalectomised, cortisone or metopirone treated guinea pigs (table V). But in this test, norepinephrine reduces the effect of PTH (fig. 1). |
