Cell-type specificity of mGluR activation in striatal neuronal subtypes |
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| Authors: | A Pisani G Bernardi P Bonsi D Centonze P Giacomini P Calabresi |
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| Institution: | (1) Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata, Rome, Italy, IT;(2) IRCCS Ospedale S. Lucia, Rome, Italy, IT;(3) II Clinica Neurologica, Università "La Sapienza", Rome, Italy, IT |
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| Abstract: | Summary. The effects of metabotropic glutamate receptor (mGluR) activation were studied in medium spiny neurons and large aspiny (LA)
interneurons by means of electrophysiological and optical recordings. DCG-IV and L-SOP, agonists for group II and III mGluRs,
respectively, produced a presynaptic inhibitory effect on corticostriatal glutamatergic excitatory postsynaptic potentials
(EPSPs) in both spiny and LA cells. Activation of group I mGluRs by the selective agonist 3,5-DHPG produced no effect on membrane
properties and glutamatergic transmission in spiny neurons, whereas it did cause a membrane depolarization in LA interneurons
coupled to increased input resistance. In combined optical and electrophysiological experiments, in spiny neurons 3,5-DHPG
enhanced membrane depolarization and intracellular calcium (Ca2+) levels induced by NMDA applications, but not in LA interneurons. These data suggest the existence of a positive interaction
between NMDA and group I mGlu receptors only in medium spiny cells which might, at least partially, account for the differential
vulnerability to excitotoxic damage observed in striatal neuronal subtypes.
Accepted September 20, 1999 |
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| Keywords: | : Amino acids Striatum Electrophysiology Metabotropic glutamate receptors Excitotoxicity |
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