Growth of Leishmania donovani Amastigotes in a Continuous Macrophage-Like Cell Culture* |
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| Authors: | RANDOLPH L. BERENS J. JOSEPH MARR |
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| Affiliation: | Departments of Medicine and Microbiology, Division of Infectious Diseases, St. Louis University School of Medicine, St. Louis, Missouri 63104 |
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| Abstract: | SYNOPSIS. The feasibility of using a macrophage-like murine tumor cell as a host for Leishmania donovani was investigated. This cell line, designated P388D1, rapidly phagocytized amastigotes and supported their intracellular replication. It can serve as a model "host" without the inherent limitations of primary macrophage cultures. |
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| Keywords: | Leishmania donovani amastigotes macrophage-like murine tumor cells, P388D1 |
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