Spingophosphonolipids in microsomes of Diplodon delodontus. Distribution and effect on the membrane microviscosity |
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| Affiliation: | 1. School of Remote Sensing and Information Engineering, Wuhan University, Wuhan 430079, China;2. School of Geodesy and Geomatics, Wuhan University, Wuhan 430079, China;3. State Key Laboratory of Information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University, Wuhan 430079, China;4. Shanghai Institute of Satellite Engineering, Shanghai 200240, China;1. Department of Physics, University of Texas Rio Grande Valley, Edinburg, TX, United States;2. Robert Vela High School, Edinburg, TX, United States;1. Department of Neurology, Azienda Universitario Ospedaliera di Cagliari and University of Cagliari, Cagliari, Italy;2. Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy;3. Multiple Sclerosis Center Laboratory, University of Cagliari, Cagliari, Italy;4. Azienda Sanitaria Locale n. 2, Olbia-Tempio, Italy;5. Department of Neurology, Azienda Ospedaliera San Francesco, Nuoro, Italy;6. Department of Neurology, Ospedale Antonio Segni, Ozieri, Italy;7. Amyotrophic Lateral Sclerosis Center, “Rita Levi Montalcini” Department of Neuroscience, University of Turin, Turin, Italy;8. Department of Neurosciences, Ophthalmology, Genetics, Rehabilitation and Child Health, University of Genoa, Genoa, Italy;9. Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy;10. Laboratory of Molecular Genetics, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Torino, Italy;11. Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute of Aging, Bethesda, MD, USA;12. Molecular Genetics Section, Laboratory of Neurogenetics, National Institute of Aging, Bethesda, MD, USA;13. Department of Neurology, Brain Science Institute, Johns Hopkins University, Baltimore, MD, USA;14. Neuroscience Institute of Torino (NIT), Turin, Italy;1. Harbin University of Science and Technology, Harbin, China;2. KTH Royal Institute of Technology, Stockholm, Sweden;1. Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100094, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;1. Asahi Rosai Hospital, Japan Labour Health and Welfare Organization, Owariasahi, Japan;2. Nagoya City University Medical School |
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| Abstract: | - 1.1. The distribution of ceramide aminoethylphosphonate (CAEP) in microsomal membranes obtained from different tissues of the bivalve mollusc Diplodon delodontus was determined.
- 2.2. The concentration of CAEP reached from 9 to 19% of the total microsomal polar lipids, depending on the kind of tissue.
- 3.3. Palmitic acid was the main fatty acid in the ceramide moiety, followed by stearic and eicosamonoenoic acids.
- 4.4. Artificial membranes were prepared with microsomal phospholipids or phospholipids plus sterols, with and without the addition of CAEP.
- 5.5. It was shown that the phosphonate confers minor mobility to the membranes. This effect is more effective when the membrane contains the natural sterols and the phospholipids are unsaturated.
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