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The effect of norepinephrine and dibutyryl cyclic adenosine monophosphate on cation transport in duck erythrocytes
Authors:D H Riddick  F M Kregenow  J Orloff
Institution:From the Laboratory of Kidney and Electrolyte Metabolism, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014.
Abstract:Freshly prepared duck erythrocytes, incubated either in plasma or an isotonic synthetic medium containing norepinephrine (K] of both media ~ 2.5 mM), maintain water and electrolyte composition in the steady state (upper steady state) for at least 90 min. If incubated in the synthetic medium without norepinephrine or in plasma to which a β-adrenergic blocking agent (propranolol) is added, the cells lose both water and electrolyte (predominantly KCl) until a new steady state is reached (lower steady state). Reaccumulation of water and electrolyte from isotonic solutions toward the upper steady-state levels requires the addition of norepinephrine and KCl. Reaccumulation is maximal when the concentration of K and norepinephrine in the medium is 15 mM and 10-7 M, respectively. Dibutyryl cyclic-AMP (10-2 M) mimics norepinephrine in lower steady-state cells. Although an analogous effect in upper steady-state cells was not established with certainty, it is proposed that the catecholamine-induced net changes in water and electrolyte movement in duck erythrocytes are a consequence of stimulation of the activity of a membrane-bound adenyl cyclase system.
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