Genetic variation in the VP4 and NSP4 genes of human rotavirus serotype 3 (G3 type) isolated in China and Japan |
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Authors: | Cao X R Akihara S Fang Z Y Nakagomi O Ushijima H |
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Institution: | Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Japan. |
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Abstract: | Sequence analyses of the VP4 and NSP4 genes were performed on twenty human isolates of serotype G3 rotavirus obtained from China and Japan. One isolate from China, CHW17, possessed P4] genotype VP4 and KUN group NSP4 genes which are associated with G2. One isolate (02/92) from Japan, which was shown to have a wider spacing between RNA segments 10 and 11 by RNA polyacrylamide gel electrophoretic analysis like AU-1, possessed P9] genotype VP4 and AU-1 group NSP4 genes. The other isolates had P8] genotype VP4 and Wa group NSP4 genes. While the nucleotide sequence conservation among the G3 VP7 genes was more than 79% (Wen et al, Arch. Virol., 1997, 142: 1481-1489), the conservation of VP4 and NSP4 genes in the same genotypes or groups was more than 85%. |
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Keywords: | rotavirus serotype 3 VP7 VP4 NSP4 |
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