Effect of ethyl alcohol on plasma testosterone level in mice

The effect of ethanol ingestion on testicular steroidogenesis in mice was evaluated by measuring plasma testosterone level. Four groups of CBA/J male mice were treated with one of the following doses of ethanol: 1.240, 0.620, 0.310 or 0.155 g ethanol/Kg body weight. A control group was given water. The data showed no effect of the treatment on testicular weight. The concentration of testosterone in the plasma was significantly reduced in animals treated with alcohol. There was also a significant relationship between the dose of alcohol and the plasma testosterone level, with the decrease in testosterone being from 2 to 18 fold in various groups.