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Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents |
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| Authors: | Zhang Hong-wang Zhou Longhu Coats Steven J McBrayer Tamara R Tharnish Phillip M Bondada Lavanya Detorio Mervi Amichai Sarah A Johns Melissa D Whitaker Tony Schinazi Raymond F |
| Affiliation: | a Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA b Veterans Affairs Medical Center, Decatur, GA 30033, USA c RFS Pharma, LLC, 1860 Montreal Road, Tucker, GA 30084, USA |
| Abstract: | Based on the anti-hepatitis C activity of 2′-C-methyl-adenosine and 2′-C-methyl-guanosine, a series of new modified purine 2′-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2′-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells. |
| Keywords: | Hepatitis C Modified purine Nucleoside analog Antiviral Adenosine deaminase |
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