Expert systems in the control of animal cell culture processes: Potentials,functions, and perspectives |
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Authors: | Konstantin B Konstantinov Weichang Zhou Fred Golini Wei-Shou Hu |
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Institution: | (1) Miles Biotechnology, 94701 Berkeley, CA, USA;(2) Department of Chemical Engineering and Materials Science, University of Minnesota, 55455 Minneapolis, MN, USA |
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Abstract: | In recent years, the development of advanced systems for bioprocess monitoring and control has become an area of intensive research. Along with traditional techniques, there are several new approaches which are increasingly being applied to bioprocess operations. Among these, of special note is expert system technology, which provides possibilities for the design of efficient bioprocess control systems with new functional capabilities. This technology has been successfully applied to variety of microbial processes at laboratory and industrial scale. The present paper analyzes the possibility for application of expert systems to animal cell cultures processes whose high complexity is well suited to expert control. The discussion focuses on the organization and the functionality of the intelligent control systems, and covers some practical aspects of their design. |
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Keywords: | mammalian cell cultures bioprocess monitoring bioprocess control expert systems artificial intelligence hybridoma cell culture |
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