Siderophore production by the pathogenic yeast, Candida albicans |
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| Authors: | A Ismail G W Bedell D M Lupan |
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| Institution: | 1. Haemostasis Research Unit, University College London, London, England;2. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy;3. Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Fondazione IRCCS Ca'' Granda Ospedale Maggiore Policlinico, Milan, Italy;1. Physics of Geological Processes (PGP), University of Oslo, PO Box 1048, Blindern, 0316 Oslo, Norway;2. Centre for Earth Evolution and Dynamics (CEED), University of Oslo, Norway;3. Institute of Geology of Ore Deposits, Petrography, Mineralogy and Geochemistry of Russian Academy of Sciences (IGEM RAS), 119017 Moscow, Russia;4. Volcanic Basin Petroleum Research (VBPR), Oslo Research Park, 0349 Oslo, Norway |
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| Abstract: | Biochemical assays were used to determine that some strains of Candida albicans were capable of simultaneous secretion of both the hydroxamate and phenolate-type siderophores when grown in a deferrated medium at 37 degrees C. All isolants of C. albicans released hydroxamate-type siderophores into the culture medium; whereas, approximately 40% of the strains simultaneously secreted phenolate-type siderophores. The presence of phenolate and hydroxamate-type siderophores in the culture medium was further confirmed by assaying the culture media with type specific siderophore-dependent bacterial auxotrophs. This is the first report showing production of both classes of siderophores by a pathogenic yeast. |
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