Ontogenetic studies on tryptophan transport into plasma membrane vesicles derived from rat brain synaptosomes: Effect of thyroid hormones |
| |
Authors: | Elisa Herrero M Carmen Aragon Javier Diez-Guerra Fernando Valdivieso Cecilio Gimenez |
| |
Institution: | (1) Departamento de Bioquímica y Biología Molecular Centro de Biología Molecular Facultad de Ciencias, Universidad, Autónoma, 28034 Madrid, Spain |
| |
Abstract: | The uptake of tryptophan at various stages of development was examined in plasma membrane vesicles derived from rat brain. The total uptake has two components Na+-dependent and Na+-independent respectively. The Na+-dependent component of the transport system appears around the 5th postnatal day and increases with the age. TheK
m value of the system does not vary during development. The Vmax increases five-fold between 14 and 35 day of postnatal life. Plasma membrane vesicles derived from T3-treated rats are able to accumulate nearly three-fold more tryptophan than nontreated rats. The results support the idea that thyroid hormones at the earlier stages of life, promote the establishment of neurotransmission in the developing nervous system. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |