HLA-DR2-associated Dw subtypes correlate with RFLP clusters: most DR2 IDDM patients belong to one of these clusters |
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Authors: | Nadine Cohen Chaim Brautbar Marie-Pierre Font Jean Dausset Daniel Cohen |
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Institution: | (1) Department of Medical and Physiological Chemistry, University of Uppsala, S-751 23, Box 575, Uppsala, Sweden;(2) Veterinary Resources Branch, National Institute of Health (NIH), 20892 Bethesda, Maryland |
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Abstract: | The incidence of arthritis and the antibody response to mouse and to rat type 11 collagen after immunization with native rat type II collagen was studied in different mouse strains, including wild mouse-derived strains belonging to the H-2p/H-2q family. High serum levels of antibodies to mouse and rat type II collagen were seen only in H-2q mice, whereas mice belonging to the p, w3, w5, and w17 haplotypes displayed low type II collagen-specific antibody responses. Mice from three different H-2q-carrying strains (DBA/1, NFR/N, and B10.G) with different non-major histocompatibility complex genes were all susceptible to collagen arthritis, but they displayed a varying incidence of arthritis and varying clinical features. No arthritis was seen in non-H-2q mice, except in the B10.CAS2 strain where a few mice developed arthritis despite very low serum levels of type II collagen-specific antibodies. We conclude that small differences in the A chain of class II transplantation antigens are of importance for the development of arthritis and for the stimulation of a high response after immunization with type 11 collagen.Abbreviations used in this paper ELISA
enzyme-linked immunosorbent assay
- PBS
phosphate-buffered saline
- Ig
immunoglobulin
- MHC
major histocompatibility complex |
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