Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents |
| |
Authors: | Kumar Atul Tripathi Vishwa Deepak Kumar Promod Gupta Lalit Prakash Akanksha Trivedi Ritu Bid Hemant Nayak V L Siddiqui Jawed A Chakravarti Bandana Saxena Ruchi Dwivedi Anila Siddiquee M I Siddiqui U Konwar Rituraj Chattopadhyay Naibedya |
| |
Affiliation: | Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226 001, India. dratulsax@gmail.com |
| |
Abstract: | A new series of 1,3-biarylsulfanyl derivatives (homodibenzyl core motif) have been designed and synthesized as new estrogen receptor ligands by chopping benzothiophene core of raloxifene to engender seco-raloxifene scaffold. All the synthesized compounds were screened for anti-proliferative, anti-osteoporotic, and anti-implantation activity. Compounds (35, 36) having basic amino anti-estrogenic side chain were exhibiting potential anti-proliferative activity in MCF-7, MDA-MB-231 and ishikawa cell lines. Some of the synthesized compounds having homodibenzyl motif (5, 8, 10) have shown moderate anti-osteoporotic activity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|