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Glutathione system in erythrocytes and blood plasma in strokes and dyscirculatory encephalopathy |
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| Authors: | L S Kolesnichenko V I Kulinsky V V Shprakh V V Bardymov N V Verlan L P Gubina G A Pensionerova M P Sergeeva L M Stanevich G T Philippova |
| Institution: | (1) Department of Bioinorganic and Bioorganic Chemistry, P.O. Box 85, 664047 Irkutsk, Russia;(2) Department of Biochemistry, Irkutsk State Medical University, P.O. Box 85, 664047 Irkutsk, Russia;(3) Department of Neurology and Neurosurgery, Irkutsk State Institute of Physician Training, Irkutsk, Russia;(4) Department of Clinical Pharmacology, Irkutsk State Institute of Physician Training, Irkutsk, Russia |
| Abstract: | Dyscirculatory encephalopathy and mild ischemic stroke are characterized by solitary changes in components of glutathione metabolism. In moderate and severe ischemic strokes essential changes have been found. Changes in glutathione metabolism are also expressed in hemorrhagic stroke. The clearest increase was found in activities of glutathione peroxidase and glutathione transferase and in rare cases in activities of glutathione reductase and GSH concentration. The increase of enzymes activity was not found in patients with delayed onset of treatment (more than 3 days) and also in severe cases terminated by subsequent death of patients. Glutathione system is obviously important for tolerance to cerebral ischemia. |
| Keywords: | glutathione system stroke dyscirculatory encephalopathy |
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