The identification of a Caenorhabditis elegans homolog of p34cdc2 kinase |
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Authors: | Hiro Mori Robert E Palmer and Paul W Sternberg |
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Institution: | (1) Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, 91125 Pasadena, CA, USA |
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Abstract: | We have identified a Caenorhabditis elegans homolog of p34cdc2 kinase. The C. elegans homolog, ncc-1, is -60% identical to p34cdc2 of Homo sapiens. When expressed from a constitutive yeast promoter, ncc-1 is capable of complementing a conditional lethal mutation in the CDC28 gene of Saccharomyces cerevisiae, indicating that this C. elegans homolog can properly regulate the cell cycle. |
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Keywords: | p34cdc2 Caenorhabditis elegans Cell cycle |
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