核糖体结构研究中的里程碑

核糖体是一个以RNA和蛋白质为基础的合成蛋白质的分子机器.其复杂的结构使它长期被结晶学家视为该研究领域中的喜马拉雅山.最近在核糖体结构研究中的突破性进展，首次在核糖体及其亚基高度复杂的电子密度图上定位了几种已知三维结构的蛋白质和许多双链rRNA区，并揭示了亚基界面的精细结构和tRNA、mRNA和核糖体间复杂的相互作用.

The Milestone for Ribosome Structure Studies

Ribosome is a molecular machine based on RNA,which provides the workshop and tools to synthesize all of the proteins in cells.Its sophisticated structure enables crystallographers regarding it as the Mount Everest for a long time.Recently ,the breakthrough has made for ribosome structure studies.For the first time,several proteins of known three-dimensional structure,and many regions of double-stranded rRNA,have been located in highly complex electron-density maps of ribosomal subunits. And the delicate structure of subunit interface and complicated tRNA,mRNA and ribosome interactions have been revealed.